Pregnancy Accelerates Biological Aging in Healthy Young Adults

Pregnancy may carry a cost, reports a new study from Columbia University Mailman School of Public Health. The research, carried out among 1,735 young people in the Philippines, shows that women who reported having been pregnant looked biologically older than women who had never been pregnant, and women who had been pregnant more often looked biologically older than those who reported fewer pregnancies. Notably, the number of pregnancies was not associated with biological aging among same-aged cohort men, which implies that there is something about pregnancy or breastfeeding specifically that accelerates biological aging in women. The findings are published in the Proceedings of National Academy of Sciences.

This study builds on epidemiological findings that high fertility can have negative side effects on women’s health and longevity. What was unknown, however, was whether the “costs” of reproduction were present earlier in life, before disease and age-related decline begin to become apparent. Until now, quantifying biological aging among the young has been difficult. This challenge was overcome using a collection of new tools that use DNA methylation (DNAm) to study different facets of cellular aging, health, and mortality risk. These tools, called “epigenetic clocks” allow researchers to study aging earlier in life, filling a key gap in the study of biological aging.

“Epigenetic clocks have revolutionized how we study biological aging across the life-course and open up new opportunities to study how and when long-term health costs of reproduction and other life events take hold,” said Calen Ryan, PhD, associate research scientist in the Columbia Aging Center, and lead author.

“Our findings suggest that pregnancy speeds up biological aging, and that these effects are apparent in young, high-fertility women,” added Ryan. “Our results are also the first to follow the same women through time, linking changes in each woman’s pregnancy number to changes in her biological age.”

The relationship between pregnancy history and biological age in women persisted even after taking into account various other factors tied to biological aging, such as socioeconomic status, smoking, and genetic variation. This finding, noted Ryan, points to some aspect of bearing children—rather than sociocultural factors associated with early fertility or sexual activity—as a driver of biological aging.

Despite the striking nature of the findings, Ryan encourages people to remember the context: “Many of the reported pregnancies in our baseline measure occurred during late adolescence when women are still growing. We expect this kind of pregnancy to be particularly challenging for a growing mother, especially if her access to health care, resources, or other forms of support is limited.”

He also acknowledged that there is more work to do, saying, “We still have a lot to learn about the role of pregnancy and other aspects of reproduction in the aging process. We also do not know the extent to which accelerated epigenetic aging in these particular individuals will manifest as poor health or mortality decades later in life,”  adding that our current understanding of epigenetic clocks and how they predict health and mortality comes largely from North America and Europe, and that the aging process can take slightly different forms in the Philippines and other places around the world.

“Ultimately I think our findings highlight the potential long-term impacts of pregnancy on women’s health, and the importance of taking care of new parents, especially young mothers,” Ryan said.

Co-authors are Christopher Kuzawa, Northwestern University, Nanette R. Lee and Delia B. Carba, USC-Office of Population Studies Foundation; Julie L. MacIsaac, David S. Lin, and Parmida Atashzay, University of British Columbia; Daniel Belsky Columbia Public Health and Columbia Aging Center; Michael S. Kobor, University of British Columbia, Canadian Institute for Advanced Research, Centre for Molecular Medicine and Therapeutics.

The study was supported by the National Institutes of Health (grant AG061006); National Science Foundation (grant 1751912); University of British Columbia (grant  60055724).