Temporal dynamics of the multi-omic response to endurance exercise training
Department of Medicine, Stanford University, Stanford, CA, USA
David Amar, David Jimenez-Morales, Malene E. Lindholm, Shruti Marwaha, Archana Natarajan Raja, Jimmy Zhen, Euan Ashley, Matthew T. Wheeler, Karen P. Dalton, Steven G. Hershman, Mihir Samdarshi & Christopher Teng
Department of Genetics, Stanford University, Stanford, CA, USA
Nicole R. Gay, Bingqing Zhao, Jose J. Almagro Armenteros, Nasim Bararpour, Si Wu, Stephen B. Montgomery, Michael P. Snyder, Clarisa Chavez, Roxanne Chiu, Krista M. Hennig, Chia-Jui Hung, Christopher A. Jin & Navid Zebarjadi
Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Pierre M. Jean-Beltran, Hasmik Keshishian, Natalie M. Clark, Steven A. Carr, D. R. Mani, Charles C. Mundorff & Cadence Pearce
Department of Internal Medicine, University of Iowa, Iowa City, IA, USA
Dam Bae, Ana C. Lira, Sue C. Bodine, Michael Cicha, Luis Gustavo Oliveira De Sousa, Bailey E. Jackson, Kyle S. Kramer, Andrea G. Marshall & Collyn Z-T. Richards
Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA
Surendra Dasari
Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA
Courtney Dennis, Julian Avila-Pacheco & Clary B. Clish
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
Charles R. Evans & Charles F. Burant
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA
David A. Gaul, Evan M. Savage & Facundo M. Fernández
Department of Medicine, Duke University, Durham, NC, USA
Olga Ilkayeva, William E. Kraus & Kim M. Huffman
Duke Molecular Physiology Institute, Duke University, Durham, NC, USA
Olga Ilkayeva, Michael J. Muehlbauer, William E. Kraus, Christopher Newgard, Kim M. Huffman & Megan E. Ramaker
Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA
Anna A. Ivanova, Xueyun Liu & Kristal M. Maner-Smith
BRCF Metabolomics Core, University of Michigan, Ann Arbor, MI, USA
Maureen T. Kachman, Alexander (Sasha) Raskind & Tanu Soni
Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN, USA
Ian R. Lanza
Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Venugopalan D. Nair, Gregory R. Smith, Yongchao Ge, Stuart C. Sealfon, Mary Anne S. Amper, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Stas Rirak, Aliza B. Rubenstein, Frederique Ruf-Zamojski, Nitish Seenarine, Sindhu Vangeti, Mital Vasoya, Alexandria Vornholt, Xuechen Yu & Elena Zaslavsky
Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
Paul D. Piehowski
Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA
Jessica L. Rooney, Russell Tracy, Elaine Cornell, Nicole Gagne & Sandy May
Department of Pathology, Stanford University, Stanford, CA, USA
Kevin S. Smith, Nikolai G. Vetr, Stephen B. Montgomery & Daniel Nachun
Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Cynthia L. Stowe, Fang-Chi Hsu, Scott Rushing & Michael P. Walkup
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA
Gina M. Many, James A. Sanford, Joshua N. Adkins, Wei-Jun Qian, Marina A. Gritsenko, Joshua R. Hansen, Chelsea Hutchinson-Bunch, Matthew E. Monroe, Ronald J. Moore, Michael D. Nestor, Vladislav A. Petyuk & Tyler J. Sagendorf
Department of Biochemistry, Emory University, Atlanta, GA, USA
Tiantian Zhang, Zhenxin Hou & Eric A. Ortlund
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA, USA
David M. Presby, Laurie J. Goodyear, Brent G. Albertson, Tiziana Caputo, Michael F. Hirshman, Nathan S. Makarewicz, Pasquale Nigro & Krithika Ramachandran
Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA
Alec Steep & Jun Z. Li
Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Yifei Sun & Martin J. Walsh
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Yifei Sun & Martin J. Walsh
Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
Sue C. Bodine
Department of Physiology and Aging, University of Florida, Gainesville, FL, USA
Karyn A. Esser & Marco Pahor
Department of Orthopaedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA
Simon Schenk
Department of Biomedical Data Science, Stanford University, Stanford, CA, USA
Stephen B. Montgomery
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA
Gary Cutter
Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
Robert E. Gerszten & Jeremy M. Robbins
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Michael E. Miller
Department of Medicine, Mayo Clinic, Rochester, MN, USA
K. Sreekumaran Nair
Department of Statistics, Stanford University, Stanford, CA, USA
Trevor Hastie & Rob Tibshirani
Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA
Rob Tibshirani
Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA
Brian Bouverat, Christiaan Leeuwenburgh & Ching-ju Lu
Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Barbara Nicklas
Department of Health and Exercise Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA
W. Jack Rejeski
National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
John P. Williams
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA
Ashley Xia
Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA
Elisabeth R. Barton
Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA
Frank W. Booth
Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA
Frank W. Booth
Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA
Frank W. Booth & R. Scott Rector
Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA
Frank W. Booth
Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA
Roger Farrar
Department of Medicine, Division of Endocrinology and Diabetes, University of California, Los Angeles, CA, USA
Andrea L. Hevener
Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA
Benjamin G. Ke & Chongzhi Zang
Section on Clinical, Behavioral, and Outcomes Research, Joslin Diabetes Center, Boston, MA, USA
Sarah J. Lessard
Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA
Andrea G. Marshall
Department of Health Sciences, Stetson University, Deland, FL, USA
Scott Powers
Department of Medicine, University of Missouri, Columbia, MO, USA
R. Scott Rector
NextGen Precision Health, University of Missouri, Columbia, MO, USA
R. Scott Rector
Cell Biology and Physiology, Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA
John Thyfault
Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA
Zhen Yan
Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA
Zhen Yan
Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA
Zhen Yan
Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA
Zhen Yan
Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA, USA
Zhen Yan
Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA
Zhen Yan
Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA
Ali Tugrul Balci & Maria Chikina
Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA
Samuel G. Moore
Department of Medicine, Emory University, Atlanta, GA, USA
Karan Uppal
Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA
Marcas Bamman & Anna Thalacker-Mercer
Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Bryan C. Bergman, Daniel H. Bessesen, Wendy M. Kohrt, Edward L. Melanson, Kerrie L. Moreau, Irene E. Schauer & Robert S. Schwartz
Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Thomas W. Buford
Human Performance Laboratory, Ball State University, Muncie, IN, USA
Toby L. Chambers, Bridget Lester, Scott Trappe & Todd A. Trappe
Translational Research Institute, AdventHealth, Orlando, FL, USA
Paul M. Coen, Bret H. Goodpaster & Lauren M. Sparks
Department of Pediatrics, University of California, Irvine, CA, USA
Dan Cooper, Fadia Haddad & Shlomit Radom-Aizik
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Kishore Gadde, Melissa Harris, Neil M. Johannsen, Tuomo Rankinen & Eric Ravussin
College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
Catherine M. Jankowski
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Nicolas Musi
Population and Public Health, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Robert L. Newton Jr
Biochemistry and Structural Biology, Center for Metabolic Health, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Blake B. Rasmussen
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA
Elena Volpi
All authors reviewed and revised the manuscript. Detailed author contributions are provided in the Supplementary Information.