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Temporal dynamics of the multi-omic response to endurance exercise training

Temporal dynamics of the multiomic response to endurance exercise training
Temporal multi-omic analysis of tissues from rats undergoing up to eight weeks of endurance exercise training reveals widespread shared, tissue-specific and sex-specific changes, including immune, metabolic, stress response and mitochondrial pathways
  • Department of Medicine, Stanford University, Stanford, CA, USA

    David Amar, David Jimenez-Morales, Malene E. Lindholm, Shruti Marwaha, Archana Natarajan Raja, Jimmy Zhen, Euan Ashley, Matthew T. Wheeler, Karen P. Dalton, Steven G. Hershman, Mihir Samdarshi & Christopher Teng

  • Department of Genetics, Stanford University, Stanford, CA, USA

    Nicole R. Gay, Bingqing Zhao, Jose J. Almagro Armenteros, Nasim Bararpour, Si Wu, Stephen B. Montgomery, Michael P. Snyder, Clarisa Chavez, Roxanne Chiu, Krista M. Hennig, Chia-Jui Hung, Christopher A. Jin & Navid Zebarjadi

  • Proteomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Pierre M. Jean-Beltran, Hasmik Keshishian, Natalie M. Clark, Steven A. Carr, D. R. Mani, Charles C. Mundorff & Cadence Pearce

  • Department of Internal Medicine, University of Iowa, Iowa City, IA, USA

    Dam Bae, Ana C. Lira, Sue C. Bodine, Michael Cicha, Luis Gustavo Oliveira De Sousa, Bailey E. Jackson, Kyle S. Kramer, Andrea G. Marshall & Collyn Z-T. Richards

  • Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA

    Surendra Dasari

  • Metabolomics Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Courtney Dennis, Julian Avila-Pacheco & Clary B. Clish

  • Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Charles R. Evans & Charles F. Burant

  • School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA

    David A. Gaul, Evan M. Savage & Facundo M. Fernández

  • Department of Medicine, Duke University, Durham, NC, USA

    Olga Ilkayeva, William E. Kraus & Kim M. Huffman

  • Duke Molecular Physiology Institute, Duke University, Durham, NC, USA

    Olga Ilkayeva, Michael J. Muehlbauer, William E. Kraus, Christopher Newgard, Kim M. Huffman & Megan E. Ramaker

  • Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA

    Anna A. Ivanova, Xueyun Liu & Kristal M. Maner-Smith

  • BRCF Metabolomics Core, University of Michigan, Ann Arbor, MI, USA

    Maureen T. Kachman, Alexander (Sasha) Raskind & Tanu Soni

  • Division of Endocrinology, Nutrition, and Metabolism, Mayo Clinic, Rochester, MN, USA

    Ian R. Lanza

  • Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Venugopalan D. Nair, Gregory R. Smith, Yongchao Ge, Stuart C. Sealfon, Mary Anne S. Amper, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Stas Rirak, Aliza B. Rubenstein, Frederique Ruf-Zamojski, Nitish Seenarine, Sindhu Vangeti, Mital Vasoya, Alexandria Vornholt, Xuechen Yu & Elena Zaslavsky

  • Environmental Molecular Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

    Paul D. Piehowski

  • Department of Pathology and Laboratory Medicine, University of Vermont, Burlington, VT, USA

    Jessica L. Rooney, Russell Tracy, Elaine Cornell, Nicole Gagne & Sandy May

  • Department of Pathology, Stanford University, Stanford, CA, USA

    Kevin S. Smith, Nikolai G. Vetr, Stephen B. Montgomery & Daniel Nachun

  • Department of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Cynthia L. Stowe, Fang-Chi Hsu, Scott Rushing & Michael P. Walkup

  • Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA

    Gina M. Many, James A. Sanford, Joshua N. Adkins, Wei-Jun Qian, Marina A. Gritsenko, Joshua R. Hansen, Chelsea Hutchinson-Bunch, Matthew E. Monroe, Ronald J. Moore, Michael D. Nestor, Vladislav A. Petyuk & Tyler J. Sagendorf

  • Department of Biochemistry, Emory University, Atlanta, GA, USA

    Tiantian Zhang, Zhenxin Hou & Eric A. Ortlund

  • Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Boston, MA, USA

    David M. Presby, Laurie J. Goodyear, Brent G. Albertson, Tiziana Caputo, Michael F. Hirshman, Nathan S. Makarewicz, Pasquale Nigro & Krithika Ramachandran

  • Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA

    Alec Steep & Jun Z. Li

  • Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Yifei Sun & Martin J. Walsh

  • Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Yifei Sun & Martin J. Walsh

  • Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA

    Sue C. Bodine

  • Department of Physiology and Aging, University of Florida, Gainesville, FL, USA

    Karyn A. Esser & Marco Pahor

  • Department of Orthopaedic Surgery, School of Medicine, University of California, San Diego, La Jolla, CA, USA

    Simon Schenk

  • Department of Biomedical Data Science, Stanford University, Stanford, CA, USA

    Stephen B. Montgomery

  • Department of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA

    Gary Cutter

  • Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA

    Robert E. Gerszten & Jeremy M. Robbins

  • Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Michael E. Miller

  • Department of Medicine, Mayo Clinic, Rochester, MN, USA

    K. Sreekumaran Nair

  • Department of Statistics, Stanford University, Stanford, CA, USA

    Trevor Hastie & Rob Tibshirani

  • Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA

    Rob Tibshirani

  • Department of Aging and Geriatric Research, University of Florida, Gainesville, FL, USA

    Brian Bouverat, Christiaan Leeuwenburgh & Ching-ju Lu

  • Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Barbara Nicklas

  • Department of Health and Exercise Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    W. Jack Rejeski

  • National Institute on Aging, National Institutes of Health, Bethesda, MD, USA

    John P. Williams

  • National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA

    Ashley Xia

  • Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA

    Elisabeth R. Barton

  • Department of Biomedical Sciences, University of Missouri, Columbia, MO, USA

    Frank W. Booth

  • Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO, USA

    Frank W. Booth

  • Department of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA

    Frank W. Booth & R. Scott Rector

  • Dalton Cardiovascular Research Center, University of Missouri, Columbia, MO, USA

    Frank W. Booth

  • Department of Kinesiology and Health Education, University of Texas, Austin, TX, USA

    Roger Farrar

  • Department of Medicine, Division of Endocrinology and Diabetes, University of California, Los Angeles, CA, USA

    Andrea L. Hevener

  • Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA

    Benjamin G. Ke & Chongzhi Zang

  • Section on Clinical, Behavioral, and Outcomes Research, Joslin Diabetes Center, Boston, MA, USA

    Sarah J. Lessard

  • Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA

    Andrea G. Marshall

  • Department of Health Sciences, Stetson University, Deland, FL, USA

    Scott Powers

  • Department of Medicine, University of Missouri, Columbia, MO, USA

    R. Scott Rector

  • NextGen Precision Health, University of Missouri, Columbia, MO, USA

    R. Scott Rector

  • Cell Biology and Physiology, Internal Medicine, University of Kansas Medical Center, Kansas City, KS, USA

    John Thyfault

  • Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, USA

    Zhen Yan

  • Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, USA

    Zhen Yan

  • Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA

    Zhen Yan

  • Department of Molecular Physiology and Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, USA

    Zhen Yan

  • Fralin Biomedical Research Institute, Center for Exercise Medicine Research at Virginia Tech Carilion, Roanoke, VA, USA

    Zhen Yan

  • Department of Human Nutrition, Foods, and Exercise, College of Agriculture and Life Sciences, Virginia Tech, Blacksburg, VA, USA

    Zhen Yan

  • Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA, USA

    Ali Tugrul Balci & Maria Chikina

  • Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA

    Samuel G. Moore

  • Department of Medicine, Emory University, Atlanta, GA, USA

    Karan Uppal

  • Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL, USA

    Marcas Bamman & Anna Thalacker-Mercer

  • Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Bryan C. Bergman, Daniel H. Bessesen, Wendy M. Kohrt, Edward L. Melanson, Kerrie L. Moreau, Irene E. Schauer & Robert S. Schwartz

  • Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Thomas W. Buford

  • Human Performance Laboratory, Ball State University, Muncie, IN, USA

    Toby L. Chambers, Bridget Lester, Scott Trappe & Todd A. Trappe

  • Translational Research Institute, AdventHealth, Orlando, FL, USA

    Paul M. Coen, Bret H. Goodpaster & Lauren M. Sparks

  • Department of Pediatrics, University of California, Irvine, CA, USA

    Dan Cooper, Fadia Haddad & Shlomit Radom-Aizik

  • Pennington Biomedical Research Center, Baton Rouge, LA, USA

    Kishore Gadde, Melissa Harris, Neil M. Johannsen, Tuomo Rankinen & Eric Ravussin

  • College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, CO, USA

    Catherine M. Jankowski

  • Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Nicolas Musi

  • Population and Public Health, Pennington Biomedical Research Center, Baton Rouge, LA, USA

    Robert L. Newton Jr

  • Biochemistry and Structural Biology, Center for Metabolic Health, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA

    Blake B. Rasmussen

  • Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA

    Elena Volpi

  • All authors reviewed and revised the manuscript. Detailed author contributions are provided in the Supplementary Information.

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