Fremantle run all over Brisbane, Port Adelaide thump Brisbane and ...

Fremantle's 23-point AFL win over Brisbane has been marred by a spate of injuries as Brennan Cox, Karl Worner and Oscar McDonald all went down in worrying fashion.

The Lions kicked the opening four goals of Sunday's match at Optus Stadium, but Fremantle piled on the next eight to secure the 14.9 (93) to 10.10 (70) win in front of 40,604 fans.

It continued a poor start to the season for last season's grand finalists Brisbane, who coughed up a 46-point lead against Carlton a week earlier on the way to a one-point loss.

The result also means both grand finalists have gone 0-2 to start the season, with Collingwood losing to GWS and Sydney.

Brisbane subbed off Darcy Gardiner at half-time due to a knee injury, while Conor McKenna's day was ended in the second half by a left hamstring issue.

But it was Fremantle who were hit the hardest on the injury front.

Jye Amiss (four goals) and Josh Treacy (three goals) were superb in attack for Fremantle, while Caleb Serong racked up a club-record 46 disposals to go with 10 clearances.

Eric Hipwood and Joe Daniher kicked three goals apiece for Brisbane.

AAP